FAN1 Antikörper (AA 167-373) (Biotin)

Produktnummer ABIN7152567

Produktdetails anti-FAN1 Antikörper (Biotin)

Target: FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))

Bindungsspezifität: AA 167-373

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAN1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Fanconi-associated nuclease 1 protein (167-373AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FAN1

Target: FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))

Andere Bezeichnung: FAN1 (FAN1 Produkte)

Synonyme: KIAA1018 antikoerper, KMIN antikoerper, MTMR15 antikoerper, 6030441H18Rik antikoerper, Mtmr15 antikoerper, fi39f01 antikoerper, mtmr15 antikoerper, si:ch211-163b1.2 antikoerper, si:ch211-201b11.2 antikoerper, wu:fd06a07 antikoerper, wu:fi39f01 antikoerper, RGD1566323 antikoerper, FANCD2 and FANCI associated nuclease 1 antikoerper, FANCD2/FANCI-associated nuclease 1 antikoerper, FAN1 antikoerper, Fan1 antikoerper, fan1 antikoerper

Hintergrund:

Background: Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5\'-3\' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3\'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5\'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3\' flap (PubMed:25430771). Also has endonuclease activity toward 5\'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).

Aliases: 6030441H18Rik antibody, Coiled coil domain containing protein MTMR15 antibody, DKFZp451H236 antibody, DKFZp686K16147 antibody, FAN1 antibody, FAN1_HUMAN antibody, FANCD2 and FANCI associated nuclease 1 antibody, FANCD2/FANCI associated nuclease 1 antibody, FANCD2/FANCI-associated nuclease 1 antibody, Fanconi associated nuclease 1 antibody, Fanconi-associated nuclease 1 antibody, hFAN1 antibody, KIAA1018 antibody, KMIN antibody, MTMR 15 antibody, MTMR15 antibody, Myotubularin related protein 15 antibody, Myotubularin-related protein 15 antibody

UniProt: Q9Y2M0

Pathways: DNA Reparatur