PIK3R1 Antikörper (pTyr368)

Produktnummer ABIN711041

Produktdetails anti-PIK3R1 Antikörper

Target: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Bindungsspezifität: pTyr368

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIK3R1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human PI3KR1 around the phosphorylation site of Tyr368 [GD(p-Y)TL]

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu PIK3R1

Target: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Andere Bezeichnung: PI3KR1 (PI3K p85a Produkte)

Synonyme: PI3CG antikoerper, PI3K antikoerper, PI3Kgamma antikoerper, PIK3 antikoerper, AGM7 antikoerper, GRB1 antikoerper, p85 antikoerper, p85-ALPHA antikoerper, PI3KA antikoerper, AA414921 antikoerper, C530050K14 antikoerper, p50alpha antikoerper, p55alpha antikoerper, p85alpha antikoerper, wu:fb65b05 antikoerper, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma antikoerper, phosphoinositide-3-kinase regulatory subunit 1 antikoerper, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta antikoerper, phosphoinositide-3-kinase, regulatory subunit 1 (alpha) antikoerper, PIK3CG antikoerper, PIK3R1 antikoerper, Pik3r1 antikoerper, Pik3cb antikoerper, pik3r1 antikoerper

Hintergrund:

Synonyms: PI3KR1phospho Y368, GRB 1, GRB1, p85 alpha, p85, P85A_HUMAN, Phosphatidylinositol 3 kinase associated p 85 alpha, Phosphatidylinositol 3 kinase regulatory 1, Phosphatidylinositol 3 kinase regulatory subunit alpha, Phosphatidylinositol 3 kinase regulatory subunit polypeptide 1 p85 alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphoinositide 3 kinase regulatory subunit 1 alpha, Phosphoinositide 3 kinase regulatory subunit 1 p85 alpha, Phosphoinositide 3 kinase regulatory subunit 1, Phosphoinositide 3 kinase regulatory subunit polypeptide 1 p85 alpha, PI3 kinase p85 subunit alpha, PI3-kinase regulatory subunit alpha, PI3-kinase subunit p85-alpha, PI3K, PI3K regulatory subunit alpha, Pi3kr1, PtdIns 3 kinase p85 alpha, PtdIns-3-kinase regulatory subunit alpha, PtdIns-3-kinase regulatory subunit p85-alpha.

Background: The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.

Molekulargewicht: 85kDa

Gen-ID: 5295

Pathways: T-Zell Rezeptor Signalweg, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, Warburg Effekt