FCRL3 Antikörper (AA 122-222) (Biotin)

Produktnummer ABIN7152659

Produktdetails anti-FCRL3 Antikörper (Biotin)

Target: FCRL3 (Fc Receptor-Like 3 (FCRL3))

Bindungsspezifität: AA 122-222

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FCRL3 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Fc receptor-like protein 3 protein (122-222AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FCRL3

Target: FCRL3 (Fc Receptor-Like 3 (FCRL3))

Andere Bezeichnung: FCRL3 (FCRL3 Produkte)

Synonyme: CD307c antikoerper, FCRH3 antikoerper, IFGP3 antikoerper, IRTA3 antikoerper, SPAP2 antikoerper, fcrh3 antikoerper, ifgp3 antikoerper, irta3 antikoerper, spap2 antikoerper, xfl1.2 antikoerper, Fc receptor like 3 antikoerper, Fc receptor-like 3 L homeolog antikoerper, Fc receptor-like 3 antikoerper, Fc receptor-like 3 S homeolog antikoerper, FCRL3 antikoerper, fcrl3.L antikoerper, fcrl3 antikoerper, fcrl3.S antikoerper

Hintergrund:

Background: Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).

Aliases: CD307c antibody, Fc receptor homolog 3 antibody, Fc receptor-like protein 3 antibody, FcR-like protein 3 antibody, FcRH3 antibody, FcRL3 antibody, FCRL3_HUMAN antibody, hIFGP3 antibody, IFGP family protein 3 antibody, IFGP3 antibody, Immune receptor translocation-associated protein 3 antibody, Immunoglobulin superfamily receptor translocation associated protein 3 antibody, IRTA3 antibody, SH2 domain-containing phosphatase anchor protein 2 antibody, SPAP2 antibody

UniProt: Q96P31