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TIGAR Antikörper (AA 24-188) (FITC)

TIGAR Reaktivität: Human Wirt: Kaninchen Polyclonal FITC
Produktnummer ABIN7153209
  • Target Alle TIGAR Antikörper anzeigen
    TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))
    Bindungsspezifität
    • 15
    • 12
    • 7
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 24-188
    Reaktivität
    • 37
    • 34
    • 5
    • 1
    • 1
    Human
    Wirt
    • 57
    • 1
    • 1
    Kaninchen
    Klonalität
    • 59
    Polyklonal
    Konjugat
    • 25
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TIGAR Antikörper ist konjugiert mit FITC
    Applikation
    Bitte anfragen
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Fructose-2,6-bisphosphatase TIGAR protein (24-188AA)
    Isotyp
    IgG
    Top Product
    Discover our top product TIGAR Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))
    Andere Bezeichnung
    TIGAR (TIGAR Produkte)
    Synonyme
    AA793651 antikoerper, AI595337 antikoerper, C79710 antikoerper, C85509 antikoerper, Tigar antikoerper, Trp53 induced glycolysis repulatory phosphatase antikoerper, Tigar antikoerper
    Hintergrund

    Background: Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:23726973, PubMed:22887998, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration, contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973).

    Aliases: 6-bisphosphatase TIGAR antibody, C12ORF5 antibody, chromosome 12 open reading frame 5 antibody, FR2BP antibody, Fructose-2,6-bisphosphatase TIGAR antibody, Fructose-2,6-bisphosphate 2-phosphatase antibody, Probable fructose 2,6 bisphosphatase TIGAR antibody, Probable fructose-2 antibody, tigar antibody, TIGAR_HUMAN antibody, TP53 induced glycolysis and apoptosis regulator antibody, TP53 induced glycolysis regulatory phosphatase antibody, TP53-induced glycolysis and apoptosis regulator antibody, Transactivated by NS3TP2 protein antibody

    UniProt
    Q9NQ88
    Pathways
    Warburg Effekt
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