Cyclin D2 Antikörper (AA 1-289)

Produktnummer ABIN7153389

Produktdetails anti-Cyclin D2 Antikörper

Target: Cyclin D2 (CCND2)

Bindungsspezifität: AA 1-289

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity purified

Immunogen: Recombinant Human G1/S-specific cyclin-D2 protein (1-289AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:500, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Cyclin D2

Target: Cyclin D2 (CCND2)

Andere Bezeichnung: CCND2 (CCND2 Produkte)

Synonyme: si:ch211-240j22.2 antikoerper, ccnd2 antikoerper, CCND2 antikoerper, kiak0002 antikoerper, zgc:162280 antikoerper, LOC100224096 antikoerper, KIAK0002 antikoerper, BF642806 antikoerper, C86853 antikoerper, Vin-1 antikoerper, Vin1 antikoerper, cD2 antikoerper, 2600016F06Rik antikoerper, AI256817 antikoerper, cyclin D2, b antikoerper, cyclin D2 S homeolog antikoerper, cyclin D2 antikoerper, G1/S-specific cyclin-D2 antikoerper, cyclin D2, a antikoerper, cyclin D2 L homeolog antikoerper, ccnd2b antikoerper, ccnd2.S antikoerper, CCND2 antikoerper, ccnd2 antikoerper, ccnd2a antikoerper, Ccnd2 antikoerper, ccnd2.L antikoerper

Hintergrund:

Background: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Aliases: CCND 2 antibody, ccnd2 antibody, CCND2_HUMAN antibody, CyclinD2 antibody, G1/S specific cyclin D2 antibody, G1/S-specific cyclin-D2 antibody, KIAK0002 antibody, MGC102758 antibody, MPPH3 antibody

UniProt: P30279

Pathways: Zellzyklus, Mitotic G1-G1/S Phases