Cyclin D3 Antikörper (AA 1-292)
-
- Target Alle Cyclin D3 (CCND3) Antikörper anzeigen
- Cyclin D3 (CCND3)
-
Bindungsspezifität
- AA 1-292
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser Cyclin D3 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- Kreuzreaktivität
- Human
- Aufreinigung
- Antigen Affinity Purified
- Immunogen
- Recombinant Human G1/S-specific cyclin-D3 protein (1-292AA)
- Isotyp
- IgG
-
-
- Applikationshinweise
- Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200, IP:1:200-1:2000,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- Cyclin D3 (CCND3)
- Andere Bezeichnung
- CCND3 (CCND3 Produkte)
- Synonyme
- zgc:103502 antikoerper, CCND3 antikoerper, 9230106B05Rik antikoerper, AA682053 antikoerper, AL024085 antikoerper, AW146355 antikoerper, C78795 antikoerper, cyclin D3 antikoerper, ccnd3 antikoerper, CCND3 antikoerper, Ccnd3 antikoerper
- Hintergrund
-
Background: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Aliases: CCND 3 antibody, Ccnd3 antibody, CCND3_HUMAN antibody, CyclinD3 antibody, D3 type cyclin antibody, G1 S specific cyclin D3 antibody, G1/S specific cyclin D3 antibody, G1/S-specific cyclin-D3 antibody
- UniProt
- P30281
- Pathways
- Zellzyklus, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process
-