Gasdermin A Antikörper (AA 64-172) (HRP)

Produktnummer ABIN7153650

Produktdetails anti-Gasdermin A Antikörper (HRP)

Target: Gasdermin A (GSDMA)

Bindungsspezifität: AA 64-172

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Gasdermin A Antikörper ist konjugiert mit HRP

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Gasdermin-A protein (64-172AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Gasdermin A

Target: Gasdermin A (GSDMA)

Andere Bezeichnung: GSDMA (GSDMA Produkte)

Synonyme: BB149167 antikoerper, Gsdm antikoerper, Gsdm1 antikoerper, Gsdma1 antikoerper, H312E antikoerper, GSDM1 antikoerper, GSDM antikoerper, gasdermin A antikoerper, Gsdma antikoerper, GSDMA antikoerper

Hintergrund:

Background: May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).

Aliases: GSDMA antibody, GSDM antibody, GSDM1 antibody, FKSG9Gasdermin-A antibody, Gasdermin-1 antibody

UniProt: Q96QA5