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GRHL2 Antikörper (AA 1-265)

GRHL2 Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7154376
  • Target Alle GRHL2 Antikörper anzeigen
    GRHL2 (Grainyhead-Like 2 (GRHL2))
    Bindungsspezifität
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-265
    Reaktivität
    • 29
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Human
    Wirt
    • 26
    • 3
    Kaninchen
    Klonalität
    • 29
    Polyklonal
    Konjugat
    • 15
    • 4
    • 3
    • 3
    • 2
    • 2
    Dieser GRHL2 Antikörper ist unkonjugiert
    Applikation
    • 24
    • 18
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Kreuzreaktivität
    Human
    Aufreinigung
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Grainyhead-like protein 2 homolog protein (1-265AA)
    Isotyp
    IgG
    Top Product
    Discover our top product GRHL2 Primärantikörper
  • Applikationshinweise
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    GRHL2 (Grainyhead-Like 2 (GRHL2))
    Andere Bezeichnung
    GRHL2 (GRHL2 Produkte)
    Synonyme
    grhl2 antikoerper, si:dkey-21k18.2 antikoerper, GRHL2 antikoerper, BOM antikoerper, DFNA28 antikoerper, TFCP2L3 antikoerper, RGD1561191 antikoerper, 0610015A08Rik antikoerper, Tcfcp2l3 antikoerper, zgc:110324 antikoerper, grainyhead-like transcription factor 2b antikoerper, grainyhead like transcription factor 2 antikoerper, grainyhead-like transcription factor 2 antikoerper, grainyhead-like 2 (Drosophila) antikoerper, grainyhead-like transcription factor 2a antikoerper, grhl2b antikoerper, GRHL2 antikoerper, Grhl2 antikoerper, grhl2a antikoerper
    Hintergrund

    Background: Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:25152456). Binds directly to the consensus DNA sequence 5\\\'-AACCGGTT-3\\\' acting as an activator and repressor on distinct target genes. During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure. Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions. Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair. In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation. In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5\\\'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293).

    Aliases: BOM antibody, Brother of mammalian grainyhead antibody, Deafness autosomal dominant 28 antibody, DFNA28 antibody, ECTDS antibody, FLJ11172 antibody, FLJ13782 antibody, Grainyhead like 2 (Drosophila) antibody, Grainyhead like 2 antibody, Grainyhead like protein 2 homolog antibody, Grainyhead like transcription factor 2 antibody, Grainyhead-like protein 2 homolog antibody, GRHL 2 antibody, GRHL2 antibody, GRHL2_HUMAN antibody, MGC149294 antibody, MGC149295 antibody, RGD1561191 antibody, TFCP2L3 antibody, Transcription factor CP2 like 3 antibody, Transcription factor CP2-like 3 antibody

    UniProt
    Q6ISB3
    Pathways
    Tube Formation
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