VAV3 Antikörper (AA 562-674) (Biotin)

Produktnummer ABIN7154661

Produktdetails anti-VAV3 Antikörper (Biotin)

Target: VAV3 (Vav 3 Oncogene (VAV3))

Bindungsspezifität: AA 562-674

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VAV3 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Guanine nucleotide exchange factor VAV3 protein (562-674AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu VAV3

Target: VAV3 (Vav 3 Oncogene (VAV3))

Andere Bezeichnung: VAV3 (VAV3 Produkte)

Synonyme: RGD1565941 antikoerper, A530094I06Rik antikoerper, AA986410 antikoerper, Idd18.1 antikoerper, vav guanine nucleotide exchange factor 3 antikoerper, vav 3 guanine nucleotide exchange factor antikoerper, vav 3 oncogene antikoerper, VAV3 antikoerper, Vav3 antikoerper

Hintergrund:

Background: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).

Aliases: FLJ40431 antibody, Guanine nucleotide exchange factor VAV3 antibody, Protein vav 3 antibody, Protein vav3 antibody, RGD1565941 antibody, VAV 3 antibody, Vav 3 guanine nucleotide exchange factor antibody, VAV 3 oncogene antibody, VAV 3 protein antibody, VAV-3 antibody, Vav3 antibody, VAV3 oncogene antibody, VAV3 protein antibody, VAV3_HUMAN antibody

UniProt: Q9UKW4

Pathways: Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung