HSPA1L Antikörper (AA 420-641)

Produktnummer ABIN7154847

Produktdetails anti-HSPA1L Antikörper

Target: HSPA1L (Heat Shock 70kDa Protein 1-Like (HSPA1L))

Bindungsspezifität: AA 420-641

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSPA1L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Heat shock 70 kDa protein 1-like protein (420-641AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu HSPA1L

Target: HSPA1L (Heat Shock 70kDa Protein 1-Like (HSPA1L))

Andere Bezeichnung: HSPA1L (HSPA1L Produkte)

Synonyme: Hsc70t antikoerper, Msh5 antikoerper, HSPA1L antikoerper, hspa1l antikoerper, MGC147483 antikoerper, Hsp70-3 antikoerper, HSP70-1L antikoerper, HSP70-HOM antikoerper, HSP70T antikoerper, hum70t antikoerper, heat shock 70kDa protein 1-like antikoerper, heat shock protein 1-like antikoerper, heat shock 70 kDa protein 1-like antikoerper, heat shock protein family A (Hsp70) member 1 like antikoerper, HSPA1L antikoerper, Hspa1l antikoerper, LOC471967 antikoerper, hspa1l antikoerper, LOC474850 antikoerper, LOC102177850 antikoerper, LOC100050904 antikoerper

Hintergrund:

Background: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).

Aliases: Heat shock 70 kDa protein 1 Hom antibody, Heat shock 70 kDa protein 1 like antibody, Heat shock 70 kDa protein 1-Hom antibody, Heat shock 70 kDa protein 1-like antibody, Heat shock 70 kDa protein 1L antibody, Heat shock 70kD protein like 1 antibody, HS71L_HUMAN antibody, HSP70 1L antibody, HSP70 HOM antibody, HSP70-Hom antibody, HSPA1L antibody, hum70t antibody, Spermatid specific heat shock protein 70 antibody

UniProt: P34931