HDAC1 Antikörper (AA 1-482)

Produktnummer ABIN7155301

Produktdetails anti-HDAC1 Antikörper

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Bindungsspezifität: AA 1-482

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Histone deacetylase 1 protein (1-482AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:100-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu HDAC1

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Andere Bezeichnung: HDAC1 (HDAC1 Produkte)

Synonyme: GON-10 antikoerper, HD1 antikoerper, RPD3 antikoerper, RPD3L1 antikoerper, CG7471 antikoerper, DHDAC1 antikoerper, DRpd3 antikoerper, DmHDAC1 antikoerper, Dmel\\CG7471 antikoerper, E(var)3-64BC antikoerper, HDAC antikoerper, HDAC-1 antikoerper, HDAC1 antikoerper, Hdac1 antikoerper, Rpd3/HDAC antikoerper, Su(var)3-26 antikoerper, Su(var)326 antikoerper, Su(var)328 antikoerper, dHDAC-1 antikoerper, dHDAC1 antikoerper, dRPD3 antikoerper, dRpd3 antikoerper, dmHDA401 antikoerper, drpd3 antikoerper, hdac1 antikoerper, l(3)04556 antikoerper, l(3)64Cc antikoerper, rpd3 antikoerper, rpd[3] antikoerper, gon-10 antikoerper, hdac1b antikoerper, rpd3l1 antikoerper, Rpd3 antikoerper, GB14706 antikoerper, hdac1-b antikoerper, chunp6919 antikoerper, hdac-1 antikoerper, mp:zf637-2-001987 antikoerper, wu:fb19h11 antikoerper, wu:fi06f03 antikoerper, zgc:101582 antikoerper, zgc:65818 antikoerper, Hdac1-ps antikoerper, MommeD5 antikoerper, ARABIDOPSIS HISTONE DEACETYLASE 1 antikoerper, ARABIDOPSIS HISTONE DEACETYLASE 19 antikoerper, ATHD1 antikoerper, ATHDA19 antikoerper, ATRPD3A antikoerper, F20D10.250 antikoerper, F20D10_250 antikoerper, HDA1 antikoerper, HDA19 antikoerper, HISTONE DEACETYLASE antikoerper, HISTONE DEACETYLASE 19 antikoerper, HISTONE DEACETYLASE19 antikoerper, RPD3A antikoerper, histone deacetylase 1 antikoerper, HDM antikoerper, ab21 antikoerper, hdac1a antikoerper, histone deacetylase 1 antikoerper, Histone deacetylase 1 antikoerper, histone deacetylase antikoerper, histone deacetylase 1 S homeolog antikoerper, histone deacetylase Rpd3 antikoerper, histone deacetylase 1 L homeolog antikoerper, HDAC1 antikoerper, hdac1.S antikoerper, LOC411503 antikoerper, hdac1 antikoerper, Hdac1 antikoerper, HD1 antikoerper, hda-1 antikoerper, hdac1.L antikoerper, LOC748850 antikoerper

Hintergrund:

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates \\\'Lys-310\\\' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

Aliases: DKFZp686H12203 antibody, GON 10 antibody, HD1 antibody, HDAC 1 antibody, HDAC1 antibody, HDAC1_HUMAN antibody, Histone deacetylase 1 antibody, Reduced potassium dependency yeast homolog like 1 antibody, RPD3 antibody, RPD3L1 antibody

UniProt: Q13547

Pathways: Neurotrophin Signalübertragung, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis