SETDB1 Antikörper (AA 1-397)

Produktnummer ABIN7155521

Produktdetails anti-SETDB1 Antikörper

Target: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Bindungsspezifität: AA 1-397

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SETDB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Ratte

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Histone-lysine N-methyltransferase SETDB1 protein (1-397AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SETDB1

Target: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Andere Bezeichnung: SETDB1 (SETDB1 Produkte)

Synonyme: ESET antikoerper, H3-K9-HMTase4 antikoerper, KG1T antikoerper, KMT1E antikoerper, TDRD21 antikoerper, AU022152 antikoerper, mKIAA0067 antikoerper, SETDB1 antikoerper, NV10069 antikoerper, fc07d03 antikoerper, si:ch211-81a5.6 antikoerper, wu:fc07d03 antikoerper, im:7143091 antikoerper, wu:fa04a12 antikoerper, wu:fj80h02 antikoerper, zgc:152899 antikoerper, SET domain bifurcated 1 antikoerper, SET domain, bifurcated 1 antikoerper, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 antikoerper, histone-lysine N-methyltransferase SETDB1 antikoerper, SET domain, bifurcated 1a antikoerper, SET domain bifurcated 1 L homeolog antikoerper, SET domain, bifurcated 1b antikoerper, SETDB1 antikoerper, Setdb1 antikoerper, MLLT11 antikoerper, LOC100120014 antikoerper, LOC100461671 antikoerper, setdb1a antikoerper, setdb1.L antikoerper, setdb1b antikoerper

Hintergrund:

Background: Histone methyltransferase that specifically trimethylates \\\'Lys-9\\\' of histone H3. H3 \\\'Lys-9\\\' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 \\\'Lys-9\\\' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone \\\'Lys-9\\\' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.

Aliases: AU022152 antibody, EC 2.1.1.43 antibody, ERG-associated protein with SET domain antibody, ESET antibody, H3 K9 HMTase 4 antibody, H3-K9-HMTase 4 antibody, H3-K9-HMTase4 antibody, Histone H3 K9 methyltransferase 4 antibody, Histone H3-K9 methyltransferase 4 antibody, Histone-lysine N-methyltransferase SETDB1 antibody, KG1T antibody, KIAA0067 antibody, KMT1E antibody, Lysine N-methyltransferase 1E antibody, MGC90670 antibody, mKIAA0067 antibody, SET domain bifurcated 1 antibody, Set domain protein, bifurcated, 1 antibody, SETB1_HUMAN antibody, Setdb1 antibody

UniProt: Q15047