SIX Homeobox 1 Antikörper (AA 144-262) (HRP)
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- Target Alle SIX Homeobox 1 (SIX1) Antikörper anzeigen
- SIX Homeobox 1 (SIX1)
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Bindungsspezifität
- AA 144-262
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SIX Homeobox 1 Antikörper ist konjugiert mit HRP
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Applikation
- ELISA
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human Homeobox protein SIX1 protein (144-262AA)
- Isotyp
- IgG
- Top Product
- Discover our top product SIX1 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- SIX Homeobox 1 (SIX1)
- Andere Bezeichnung
- SIX1 (SIX1 Produkte)
- Synonyme
- BOS3 antikoerper, DFNA23 antikoerper, TIP39 antikoerper, BB138287 antikoerper, six1b antikoerper, six2 antikoerper, zgc:92332 antikoerper, XSix1 antikoerper, six1 antikoerper, zgc:77345 antikoerper, SIX homeobox 1 antikoerper, sine oculis-related homeobox 1 antikoerper, SIX homeobox 1a antikoerper, SIX homeobox 1 L homeolog antikoerper, SIX homeobox 1b antikoerper, SIX1 antikoerper, Six1 antikoerper, six1a antikoerper, six1.L antikoerper, six1b antikoerper
- Hintergrund
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Background: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5\'-TCA[AG][AG]TTNC-3\' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.
Aliases: BOS3 antibody, DFNA23 antibody, Homeobox protein SIX1 antibody, OTTHUMP00000179042 antibody, Sine oculis homeobox homolog 1 antibody, SIX homeobox 1 antibody, SIX1 antibody, SIX1_HUMAN antibody, TIP39 antibody
- UniProt
- Q15475
- Pathways
- Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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