ALOXE3 Antikörper (AA 1-280)

Produktnummer ABIN7155980

Produktdetails anti-ALOXE3 Antikörper

Target: ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))

Bindungsspezifität: AA 1-280

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALOXE3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Hydroperoxide isomerase ALOXE3 protein (1-280AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ALOXE3

Target: ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))

Andere Bezeichnung: ALOXE3 (ALOXE3 Produkte)

Synonyme: e-lox antikoerper, elox3 antikoerper, ARCI3 antikoerper, E-LOX antikoerper, eLOX3 antikoerper, e-LOX-3 antikoerper, ALOX15B antikoerper, arachidonate lipoxygenase 3 antikoerper, arachidonate lipoxygenase 3 L homeolog antikoerper, arachidonate 15-lipoxygenase, type B antikoerper, ALOXE3 antikoerper, aloxe3.L antikoerper, aloxe3 antikoerper, Aloxe3 antikoerper, ALOX15B antikoerper

Hintergrund:

Background: Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.

Aliases: ALOXE3 antibody, Arachidonate lipoxygenase 3 antibody, e LOX 3 antibody, E LOX antibody, e-LOX-3 antibody, eLOX3 antibody, Epidermal lipoxygenase antibody, Epidermis-type lipoxygenase 3 antibody, Lipoxygenase 3 antibody, LOXE3_HUMAN antibody

UniProt: Q9BYJ1

Pathways: Cell-Cell Junction Organization