KPNA4 Antikörper (AA 51-239) (FITC)

Produktnummer ABIN7156124

Produktdetails anti-KPNA4 Antikörper (FITC)

Target: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Bindungsspezifität: AA 51-239

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KPNA4 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Importin subunit alpha-3 protein (51-239AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KPNA4

Target: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Andere Bezeichnung: KPNA4 (KPNA4 Produkte)

Hintergrund:

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Aliases: FLJ31113 antibody, IMA3_HUMAN antibody, Importin alpha 3 antibody, Importin alpha 4 subunit antibody, Importin alpha Q1 antibody, Importin subunit alpha 3 antibody, Importin subunit alpha-3 antibody, IPO A3 antibody, IPOA 3 antibody, IPOA3 antibody, Karyopherin alpha 4 (importin alpha 3) antibody, Karyopherin alpha 4 antibody, Karyopherin alpha 4 importin alpha 3 antibody, Karyopherin alpha 4 subunit antibody, Karyopherin subunit alpha 4 antibody, Karyopherin subunit alpha-4 antibody, KPNA 4 antibody, Kpna4 antibody, MGC12217 antibody, MGC26703 antibody, OTTHUMP00000213880 antibody, QIP 1 antibody, Qip1 antibody, Qip1 protein antibody, SRP 3 antibody, SRP3 antibody

UniProt: O00629

Pathways: Protein targeting to Nucleus