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IRF7 Antikörper (AA 131-289) (FITC)

IRF7 Reaktivität: Human Wirt: Kaninchen Polyclonal FITC
Produktnummer ABIN7156633
  • Target Alle IRF7 Antikörper anzeigen
    IRF7 (Interferon Regulatory Factor 7 (IRF7))
    Bindungsspezifität
    • 16
    • 16
    • 15
    • 11
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 131-289
    Reaktivität
    • 74
    • 55
    • 54
    • 17
    • 8
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 64
    • 11
    Kaninchen
    Klonalität
    • 55
    • 20
    Polyklonal
    Konjugat
    • 22
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser IRF7 Antikörper ist konjugiert mit FITC
    Applikation
    Bitte anfragen
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Interferon regulatory factor 7 protein (131-289AA)
    Isotyp
    IgG
    Top Product
    Discover our top product IRF7 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    IRF7 (Interferon Regulatory Factor 7 (IRF7))
    Andere Bezeichnung
    IRF7 (IRF7 Produkte)
    Synonyme
    wu:fl24c03 antikoerper, zgc:66043 antikoerper, zgc:77947 antikoerper, IRF7 antikoerper, irf7 antikoerper, IRF-7H antikoerper, IRF7A antikoerper, IRF7B antikoerper, IRF7C antikoerper, IRF7H antikoerper, interferon regulatory factor 7 antikoerper, irf7 antikoerper, IRF7 antikoerper, Irf7 antikoerper
    Hintergrund

    Background: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

    Aliases: IMD39 antibody, Interferon regulatory factor 7 antibody, Interferon regulatory factor 7H antibody, IRF 7 antibody, IRF 7A antibody, IRF 7H antibody, IRF-7 antibody, IRF7 antibody, IRF7_HUMAN antibody, IRF7A antibody, IRF7B antibody, IRF7C antibody, IRF7H antibody

    UniProt
    Q92985
    Pathways
    TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagie
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