IFITM3 Antikörper (AA 1-57)

Produktnummer ABIN7156687

Produktdetails anti-IFITM3 Antikörper

Target: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Bindungsspezifität: AA 1-57

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFITM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Interferon-induced transmembrane protein 3 protein (1-57AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu IFITM3

Target: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Andere Bezeichnung: IFITM3 (IFITM3 Produkte)

Synonyme: 1110004C05Rik antikoerper, Cd225 antikoerper, Cdw217 antikoerper, DSPA2b antikoerper, Fgls antikoerper, IP15 antikoerper, mil-1 antikoerper, 1-8U antikoerper, rat8 antikoerper, Interferon-induced transmembrane protein 3 antikoerper, interferon induced transmembrane protein 3 antikoerper, ifm3 antikoerper, Ifitm3 antikoerper, IFITM3 antikoerper

Hintergrund:

Background: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

Aliases: 1 8U antibody, Fragilis antibody, IFITM3 antibody, IFM3_HUMAN antibody, Interferon induced transmembrane protein 3 (1 8U) antibody, Interferon Induced Transmembrane Protein 3 antibody, Interferon inducible antibody, Interferon inducible protein 1 8U antibody, Interferon Inducible Protein 15 antibody, Interferon Inducible Protein Homolog antibody, Interferon-induced transmembrane protein 3 antibody, Interferon-inducible protein 1-8U antibody, IP15 antibody

UniProt: Q01628