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IRAK4 Antikörper (AA 1-220)

IRAK4 Reaktivität: Human WB, ELISA, IP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7156752
  • Target Alle IRAK4 Antikörper anzeigen
    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
    Bindungsspezifität
    • 36
    • 16
    • 15
    • 11
    • 8
    • 8
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-220
    Reaktivität
    • 112
    • 64
    • 27
    • 15
    • 14
    • 12
    • 3
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 105
    • 12
    • 1
    Kaninchen
    Klonalität
    • 105
    • 13
    Polyklonal
    Konjugat
    • 48
    • 8
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IRAK4 Antikörper ist unkonjugiert
    Applikation
    • 108
    • 49
    • 37
    • 26
    • 17
    • 14
    • 12
    • 8
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
    Kreuzreaktivität
    Human
    Aufreinigung
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Interleukin-1 receptor-associated kinase 4 protein (1-220AA)
    Isotyp
    IgG
    Top Product
    Discover our top product IRAK4 Primärantikörper
  • Applikationshinweise
    Recommended dilution: WB:1:500-1:2000, IP:1:200-1:2000, IP:1:200-1:2000,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
    Andere Bezeichnung
    IRAK4 (IRAK4 Produkte)
    Synonyme
    zgc:55553 antikoerper, IRAK4 antikoerper, ipd1 antikoerper, irak-4 antikoerper, ny-ran-64 antikoerper, ny-ren-64 antikoerper, ren64 antikoerper, irak4 antikoerper, IPD1 antikoerper, IRAK-4 antikoerper, NY-REN-64 antikoerper, REN64 antikoerper, 8430405M07Rik antikoerper, 9330209D03Rik antikoerper, interleukin 1 receptor associated kinase 4 antikoerper, interleukin-1 receptor-associated kinase 4 antikoerper, IRAK4 antikoerper, irak4 antikoerper, Irak4 antikoerper
    Hintergrund

    Background: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

    Aliases: IL-1 receptor-associated kinase 4 antibody, Interleukin 1 receptor associated kinase 4 mutant form 1 antibody, Interleukin-1 receptor-associated kinase 4 antibody, Interleukin1 receptor associated kinase 4 antibody, IPD1 antibody, IRAK 4 antibody, IRAK-4 antibody, IRAK4 antibody, IRAK4 mutated form 1 antibody, IRAK4_HUMAN antibody, LOC 51135 antibody, NY REN 64 antibody, NY REN 64 antigen antibody, NY-REN-64 antibody, REN64 antibody, Renal carcinoma antigen NY-REN-64 antibody

    UniProt
    Q9NWZ3
    Pathways
    NF-kappaB Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades
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