LRRK2 Antikörper (AA 2029-2275)
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- Target Alle LRRK2 Antikörper anzeigen
- LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))
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Bindungsspezifität
- AA 2029-2275
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser LRRK2 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human Leucine-rich repeat serine/threonine-protein kinase 2 protein (2029-2275AA)
- Isotyp
- IgG
- Top Product
- Discover our top product LRRK2 Primärantikörper
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- Applikationshinweise
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))
- Andere Bezeichnung
- LRRK2 (LRRK2 Produkte)
- Synonyme
- LRRK2 antikoerper, AURA17 antikoerper, DARDARIN antikoerper, PARK8 antikoerper, RIPK7 antikoerper, ROCO2 antikoerper, 4921513O20Rik antikoerper, 9330188B09Rik antikoerper, AW561911 antikoerper, D630001M17Rik antikoerper, Gm927 antikoerper, cI-46 antikoerper, leucine-rich repeat kinase 2 antikoerper, leucine rich repeat kinase 2 antikoerper, lrrk2 antikoerper, LRRK2 antikoerper, Lrrk2 antikoerper
- Hintergrund
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Background: Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH , and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
Aliases: augmented in rheumatoid arthritis 17 antibody, AURA17 antibody, Dardarin antibody, Leucine rich repeat kinase 2 antibody, leucine rich repeat serine threonine protein kinase 2 antibody, Leucine-rich repeat serine/threonine-protein kinase 2 antibody, LRRK 2 antibody, LRRK2 antibody, LRRK2_HUMAN antibody, PARK 8 antibody, PARK8 antibody, RIPK7 antibody, ROCO 2 antibody, ROCO2 antibody
- UniProt
- Q5S007
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
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