LAIR1 Antikörper (AA 22-165)

Produktnummer ABIN7158291

Produktdetails anti-LAIR1 Antikörper

Target: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Bindungsspezifität: AA 22-165

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LAIR1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Leukocyte-associated immunoglobulin-like receptor 1 protein (22-165AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu LAIR1

Target: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Andere Bezeichnung: LAIR1 (LAIR1 Produkte)

Synonyme: 5133400O11Rik antikoerper, BB115266 antikoerper, D7Bwg0421e antikoerper, Lair-1 antikoerper, mLair-1 antikoerper, CD305 antikoerper, LAIR-1 antikoerper, leukocyte-associated Ig-like receptor 1 antikoerper, leukocyte associated immunoglobulin like receptor 1 antikoerper, leukocyte-associated immunoglobulin-like receptor 1 antikoerper, Lair1 antikoerper, LAIR1 antikoerper

Hintergrund:

Background: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

Aliases: 5133400O11Rik antibody, CD305 antibody, D7Bwg0421e antibody, hLAIR1 antibody, LAIR 1 antibody, LAIR-1 antibody, LAIR1 antibody, LAIR1 protein antibody, LAIR1_HUMAN antibody, Leukocyte associated Ig like receptor 1 antibody, Leukocyte associated immunoglobulin like receptor 1 antibody, Leukocyte-associated immunoglobulin-like receptor 1 antibody

UniProt: Q6GTX8