LRP8 Antikörper (AA 131-332) (HRP)
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- Target Alle LRP8 Antikörper anzeigen
- LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))
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Bindungsspezifität
- AA 131-332
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser LRP8 Antikörper ist konjugiert mit HRP
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Applikation
- ELISA
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human Low-density lipoprotein receptor-related protein 8 protein (131-332AA)
- Isotyp
- IgG
- Top Product
- Discover our top product LRP8 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- LRP8 (Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor (LRP8))
- Andere Bezeichnung
- LRP8 (LRP8 Produkte)
- Synonyme
- LRP8 antikoerper, APOER2 antikoerper, HSZ75190 antikoerper, LRP-8 antikoerper, MCI1 antikoerper, 4932703M08Rik antikoerper, AA921429 antikoerper, AI848122 antikoerper, ApoER2 antikoerper, Lr8b antikoerper, LR8B antikoerper, LDL receptor related protein 8 antikoerper, low density lipoprotein receptor-related protein 8, apolipoprotein e receptor antikoerper, LRP8 antikoerper, Lrp8 antikoerper
- Hintergrund
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Background: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
Aliases: APOER2 antibody, Apolipoprotein E receptor 2 antibody, low density lipoprotein receptor-related protein 8 antibody, Low-density lipoprotein receptor-related protein 8 antibody, LRP-8 antibody, LRP8 antibody, LRP8_HUMAN antibody
- UniProt
- Q14114
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