BRCC3 Antikörper (AA 1-316)

Produktnummer ABIN7158678

Produktdetails anti-BRCC3 Antikörper

Target: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Bindungsspezifität: AA 1-316

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRCC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Lys-63-specific deubiquitinase BRCC36 protein (1-316AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BRCC3

Target: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Andere Bezeichnung: BRCC3 (BRCC3 Produkte)

Synonyme: CXorf53 antikoerper, BRCC3 antikoerper, xtp1 antikoerper, brcc3 antikoerper, BRCC36 antikoerper, brcc36 antikoerper, C6.1A antikoerper, BRCA1/BRCA2-containing complex subunit 3 antikoerper, DEP domain containing 1B antikoerper, BRCA1/BRCA2-containing complex, subunit 3 antikoerper, BRCA1/BRCA2-containing complex subunit 3 L homeolog antikoerper, BRCC3 antikoerper, depdc1b antikoerper, brcc3 antikoerper, Brcc3 antikoerper, brcc3.L antikoerper

Hintergrund:

Background: Metalloprotease that specifically cleaves \\\'Lys-63\\\'-linked polyubiquitin chains. Does not have activity toward \\\'Lys-48\\\'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes \\\'Lys-63\\\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes \\\'Lys-63\\\'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves \\\'Lys-63\\\'-linked ubiquitin in various substrates. Mediates the specific \\\'Lys-63\\\'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.

Aliases: BRCA1-A complex subunit BRCC36 antibody, BRCA1/BRCA2 containing complex subunit 3 antibody, BRCA1/BRCA2 containing complex subunit 36 antibody, BRCA1/BRCA2-containing complex subunit 3 antibody, BRCA1/BRCA2-containing complex subunit 36 antibody, Brcc3 antibody, BRCC3_HUMAN antibody, BRCC36 antibody, BRISC complex subunit BRCC36 antibody, C6.1A antibody, Chromosome X open reading frame 53 antibody, CXorf53 antibody, Lys-63-specific deubiquitinase BRCC36 antibody, OTTHUMP00000061450 antibody

UniProt: P46736

Pathways: Positive Regulation of Response to DNA Damage Stimulus