PRNP Antikörper (AA 23-64)

Produktnummer ABIN7158932

Produktdetails anti-PRNP Antikörper

Target: PRNP (Prion Protein (PRNP))

Bindungsspezifität: AA 23-64

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRNP Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Major prion protein (23-64AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PRNP

Target: PRNP (Prion Protein (PRNP))

Andere Bezeichnung: PRNP (PRNP Produkte)

Synonyme: ASCR antikoerper, AltPrP antikoerper, CD230 antikoerper, CJD antikoerper, GSS antikoerper, KURU antikoerper, PRIP antikoerper, PrP antikoerper, PrP27-30 antikoerper, PrP33-35C antikoerper, PrPc antikoerper, p27-30 antikoerper, Prn antikoerper, Prn-p antikoerper, prp antikoerper, cjd antikoerper, prion antikoerper, prp(c) antikoerper, MGC84114 antikoerper, PRP antikoerper, PRPC antikoerper, Prp antikoerper, SIP antikoerper, PRNP antikoerper, AA960666 antikoerper, AI325101 antikoerper, PrP antikoerper, PrPC antikoerper, PrPSc antikoerper, Prn-i antikoerper, Sinc antikoerper, prP27-30 antikoerper, prP33-35C antikoerper, PrP-1 antikoerper, PrP1 antikoerper, prnprs1 antikoerper, stPrP-1 antikoerper, zgc:123004 antikoerper, prion protein antikoerper, prion protein S homeolog antikoerper, prion protein b antikoerper, PRNP antikoerper, Prnp antikoerper, prnp.S antikoerper, prnpb antikoerper

Hintergrund:

Background: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

Aliases: Alternative prion protein, major prion protein antibody, AltPrP antibody, ASCR antibody, CD230 antibody, CD230 antigen antibody, CJD antibody, GSS antibody, KURU antibody, Major prion protein antibody, p27 30 antibody, PRIO_HUMAN antibody, Prion protein antibody, Prion related protein antibody, PRIP antibody, PRNP antibody, PrP antibody, PrP27 30 antibody, PrP27-30 antibody, PrP33-35C antibody, PrPC antibody, PrPSc antibody, Sinc antibody

UniProt: P04156

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation