MCTS1 Antikörper (AA 1-181) (HRP)

Produktnummer ABIN7158952

Produktdetails anti-MCTS1 Antikörper (HRP)

Target: MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))

Bindungsspezifität: AA 1-181

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCTS1 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Malignant T-cell-amplified sequence 1 protein (1-181AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MCTS1

Target: MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))

Andere Bezeichnung: MCTS1 (MCTS1 Produkte)

Synonyme: MCT-1 antikoerper, MCT1 antikoerper, MCT1a antikoerper, cb517 antikoerper, zgc:55682 antikoerper, 1500019M23Rik antikoerper, zgc:56242 antikoerper, mcts1 antikoerper, MGC89874 antikoerper, MCTS1 antikoerper, MCT-1A antikoerper, mct-1 antikoerper, mct1 antikoerper, MCT-1B antikoerper, mcts1-a antikoerper, mcts1-b antikoerper, MCTS1, re-initiation and release factor antikoerper, solute carrier family 16 (monocarboxylate transporter), member 1b antikoerper, malignant T cell amplified sequence 1 antikoerper, malignant T-cell amplified sequence 1 antikoerper, solute carrier family 16 member 1 antikoerper, malignant T-cell amplified sequence 1 S homeolog antikoerper, monocarboxylate transporter 1 antikoerper, malignant T-cell amplified sequence 1 L homeolog antikoerper, MCTS1 antikoerper, slc16a1b antikoerper, Mcts1 antikoerper, mcts1 antikoerper, SLC16A1 antikoerper, mcts1.S antikoerper, MCT1 antikoerper, mcts1.L antikoerper

Hintergrund:

Background: Anti-oncogene that play a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation, promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer, recruits the density-regulated protein/DENR and binds to the cap complex of the 5\'-terminus of mRNAs, subsequently altering the mRNA translation profile, up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation, promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

Aliases: FLJ39637 antibody, Malignant T cell amplified sequence 1 antibody, Malignant T cell-amplified sequence 1 antibody, MCT 1 antibody, MCT-1 antibody, MCT1 antibody, MCTS 1 antibody, MCTS1 antibody, MCTS1_HUMAN antibody, Multiple copies T cell malignancies 1 antibody, Multiple copies T cell malignancies antibody, Multiple copies T-cell malignancies antibody, Oncogene MCT 1 antibody, Oncogene MCT1 antibody

UniProt: Q9ULC4