MED1 Antikörper (AA 878-1031)

Produktnummer ABIN7159100

Produktdetails anti-MED1 Antikörper

Target: MED1 (Mediator Complex Subunit 1 (MED1))

Bindungsspezifität: AA 878-1031

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MED1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Mediator of RNA polymerase II transcription subunit 1 protein (878-1031AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MED1

Target: MED1 (Mediator Complex Subunit 1 (MED1))

Andere Bezeichnung: MED1 (MED1 Produkte)

Hintergrund:

Background: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

Aliases: Activator-recruited cofactor 205 kDa component antibody, ARC205 antibody, CRSP1 antibody, CRSP200 antibody, DRIP205 antibody, DRIP230 antibody, MED1 antibody, MED1_HUMAN antibody, Mediator complex subunit 1 antibody, Mediator of RNA polymerase II transcription subunit 1 antibody, p53 regulatory protein RB18A antibody, PBP antibody, Peroxisome proliferator-activated receptor-binding protein antibody, PPAR binding protein antibody, PPAR-binding protein antibody, PPARBP antibody, PPARGBP antibody, RB18A antibody, Thyroid hormone receptor-associated protein complex 220 kDa component antibody, Thyroid receptor-interacting protein 2 antibody, TR-interacting protein 2 antibody, Trap220 antibody, TRIP-2 antibody, TRIP2 antibody, Vitamin D receptor-interacting protein complex component DRIP205 antibody

UniProt: Q15648

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha