RIKEN cDNA 4930404A10 Gene (4930404A10RIK) (AA 18-91) Antikörper

Produktnummer ABIN7159183

Produktdetails

Target: RIKEN cDNA 4930404A10 Gene (4930404A10RIK)

Bindungsspezifität: AA 18-91

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Meiosis-specific kinetochore protein (18-91AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Antigendetails

Target: RIKEN cDNA 4930404A10 Gene (4930404A10RIK)

Andere Bezeichnung: MEIKIN (4930404A10RIK Produkte)

Synonyme: 4930404A10Rik antikoerper, meiotic kinetochore factor antikoerper, Meikin antikoerper

Hintergrund:

Background: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.

Aliases: MEIKINMeiosis-specific kinetochore protein antibody

UniProt: A0A087WXM9