MAGEA2 Antikörper (AA 1-104) (Biotin)

Produktnummer ABIN7159257

Produktdetails anti-MAGEA2 Antikörper (Biotin)

Target: MAGEA2 (Melanoma Antigen Family A, 2 (MAGEA2))

Bindungsspezifität: AA 1-104

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAGEA2 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Melanoma-associated antigen 2 protein (1-104AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MAGEA2

Target: MAGEA2 (Melanoma Antigen Family A, 2 (MAGEA2))

Andere Bezeichnung: MAGEA2 (MAGEA2 Produkte)

Synonyme: Mage-a2 antikoerper, MAGEA2 antikoerper, CT1.2 antikoerper, MAGE2 antikoerper, MAGEA2A antikoerper, melanoma antigen, family A, 2 antikoerper, melanoma-associated antigen 2 antikoerper, MAGE family member A2 antikoerper, Magea2 antikoerper, LOC706218 antikoerper, MAGEA2 antikoerper

Hintergrund:

Background: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Aliases: MAGEA2 antibody, MAGE2 antibody, MAGEA2A, antibody, MAGEA2B antibody, MAGE2 antibody, MAGEA2 antibody, Melanoma-associated antigen 2 antibody, Cancer/testis antigen 1.2 antibody, CT1.2 antibody, MAGE-2 antigen antibody

UniProt: P43356