Menin Antikörper (AA 1-615)

Produktnummer ABIN7159407

Produktdetails anti-Menin Antikörper

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Bindungsspezifität: AA 1-615

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Menin Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Menin protein (1-615AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Menin

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Andere Bezeichnung: MEN1 (MEN1 Produkte)

Synonyme: MEAI antikoerper, SCG2 antikoerper, menin antikoerper, meai antikoerper, scg2 antikoerper, AW045611 antikoerper, menin 1 antikoerper, menin 1 L homeolog antikoerper, multiple endocrine neoplasia I antikoerper, multiple endocrine neoplasia 1 antikoerper, MEN1 antikoerper, men1 antikoerper, men1.L antikoerper, Men1 antikoerper

Hintergrund:

Background: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates \\\'Lys-4\\\' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.

Aliases: MEA 1 antibody, MEA1 antibody, MEN 1 antibody, Men1 antibody, MEN1_HUMAN antibody, Menin antibody, Multiple Endocrine Adenomatosis 1 antibody, Multiple Endocrine Neoplasia 1 antibody, SCG 2 antibody, SCG2 antibody, Suppressor Candidate Gene 2 antibody, Wermer syndrome antibody, ZES antibody, Zollinger Ellison Syndrome antibody

UniProt: O00255

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity