MFGE8 Antikörper

Produktnummer ABIN7159679

Produktdetails anti-MFGE8 Antikörper

Target: MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MFGE8 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Protein G purified

Immunogen: Recombinant Human MFGE8 protein

Klon: 2B2D10

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Recommended dilution:IHC:1:50-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MFGE8

Target: MFGE8 (Milk Fat Globule-EGF Factor 8 Protein (MFGE8))

Andere Bezeichnung: MFGE8 (MFGE8 Produkte)

Synonyme: BA46 antikoerper, EDIL1 antikoerper, HMFG antikoerper, HsT19888 antikoerper, MFG-E8 antikoerper, MFGM antikoerper, OAcGD3S antikoerper, SED1 antikoerper, SPAG10 antikoerper, hP47 antikoerper, ba46 antikoerper, edil1 antikoerper, oacgd3s antikoerper, MGC75581 antikoerper, hst19888 antikoerper, MGC145109 antikoerper, MFGE8 antikoerper, mfge8 antikoerper, zgc:154157 antikoerper, MGC99228 antikoerper, AA408458 antikoerper, AI325141 antikoerper, Mfgm antikoerper, P47 antikoerper, lactadherin antikoerper, AGS antikoerper, MFGME8 antikoerper, MFGMP-E8 antikoerper, im:6895406 antikoerper, mfge8l antikoerper, zgc:110846 antikoerper, milk fat globule-EGF factor 8 protein antikoerper, milk fat globule-EGF factor 8 protein b antikoerper, milk fat globule-EGF factor 8 protein L homeolog antikoerper, milk fat globule-EGF factor 8 protein a antikoerper, MFGE8 antikoerper, mfge8 antikoerper, mfge8b antikoerper, mfge8.L antikoerper, Mfge8 antikoerper, mfge8a antikoerper

Hintergrund:

Background: Human MFGE8(milk fat globule-EGF factor 8,also lactadherin, breast epithelial antigen BA46, and medin) is a 46 kDa, secreted, monomeric glycoprotein that is associated with the human milk fat globule (HMFG) membrane.It is expressed by mammary epithelial cell surfaces, artery media, and in several carcinomas .Human MGFE8 is synthesized as a 387 amino acid (aa) precursor that contains a 23 aa signal sequence and a 364 aa mature region. The mature molecule contains four Nlinked glycosylation sites, an aminoterminal EGF like domain, plus C1 and C2 Iglike domains which are related to discoidin I and homologous to those of human coagulation factors V and VIII . Within the EGF like domain is an ArgGlyAsp(RGD) sequence, which is strategically placed in a hairpin loop between two antiparallel beta strands. In this way, the EGFlike domain serves as a scaffold for the RGD sequence, which is proposed to promote cell adhesion by binding cellsurface integrin receptors, such as ??v??3. Human MFGE8 shares 59 % , 58 %, 56 %, and 52 % aa sequence identity with porcine, bovine, rat, and mouse MFGE8,respectively. Functionally, MFGE8 in milk is reported to block rotavirus infection . MFGE8 expression by macrophages promotes the phagocytosis of apoptotic thymocytes by forming a bridge between phosphatidylserine on apoptotic cells, and ??v??3 integrin on phagocytes . The MFGE8 expression by macrophages controls the accumulation of apoptotic membrane fragments in atherosclerotic plaques and substantially limits lesion development .

Aliases: Lactadherin,Breast epithelial antigen,BA46 ,HMFG,MFGM Milk fat globule-EGF factor 8

UniProt: Q08431

Pathways: SARS-CoV-2 Protein Interaktom