PLD6 Antikörper (AA 1-252)

Produktnummer ABIN7159837

Produktdetails anti-PLD6 Antikörper

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Bindungsspezifität: AA 1-252

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLD6 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Mitochondrial cardiolipin hydrolase protein (1-252AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PLD6

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Andere Bezeichnung: PLD6 (PLD6 Produkte)

Synonyme: ZUC antikoerper, 4933433K01Rik antikoerper, Gm10 antikoerper, Zuc antikoerper, mZuc antikoerper, mitoPLD antikoerper, pld6 antikoerper, fc55d08 antikoerper, wu:fc55d08 antikoerper, phospholipase D family member 6 antikoerper, phospholipase D family, member 6 antikoerper, phospholipase D family member 6 S homeolog antikoerper, PLD6 antikoerper, Pld6 antikoerper, pld6.S antikoerper, pld6 antikoerper

Hintergrund:

Background: Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5\' phosphate and 3\' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (PubMed:17028579, PubMed:26711011).

Aliases: Choline phosphatase 6 antibody, Mitochondrial cardiolipin hydrolase antibody, Mitochondrial phospholipase antibody, MitoPLD antibody, Phosphatidylcholine hydrolyzing phospholipase D6 antibody, Phosphatidylcholine-hydrolyzing phospholipase D6 antibody, Phospholipase D family member 6 antibody, Phospholipase D6 antibody, PLD 6 antibody, pld6 antibody, PLD6_HUMAN antibody, Protein zucchini homolog antibody, ZUC antibody, Zucchini, Drosophila, homolog of antibody

UniProt: Q8N2A8

Pathways: Ribonucleoprotein Complex Subunit Organization