JNK2 Antikörper (AA 1-424)

Produktnummer ABIN7160013

Produktdetails anti-JNK2 Antikörper

Target: JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))

Bindungsspezifität: AA 1-424

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JNK2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Mitogen-activated protein kinase 9 protein (1-424AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:200-1:500, IP:1:200-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu JNK2

Target: JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))

Andere Bezeichnung: MAPK9 (MAPK9 Produkte)

Synonyme: MAPK9 antikoerper, JNK-55 antikoerper, JNK2 antikoerper, JNK2A antikoerper, JNK2ALPHA antikoerper, JNK2B antikoerper, JNK2BETA antikoerper, PRKM9 antikoerper, SAPK antikoerper, SAPK1a antikoerper, p54a antikoerper, p54aSAPK antikoerper, AI851083 antikoerper, Prkm9 antikoerper, JNK2-ALPHA1 antikoerper, MAP kinase 9 antikoerper, mitogen-activated protein kinase 9 antikoerper, MAP kinase 9 antikoerper, MAPK9 antikoerper, Mapk9 antikoerper, MPK9 antikoerper

Hintergrund:

Background: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock. MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Aliases: c Jun kinase 2 antibody, C Jun N terminal kinase 2 antibody, c-Jun N-terminal kinase 2 antibody, JNK 55 antibody, JNK-55 antibody, JNK2 alpha antibody, JNK2 antibody, JNK2 beta antibody, JNK2A antibody, JNK2alpha antibody, JNK2B antibody, JNK2BETA antibody, Jun kinase antibody, MAP kinase 9 antibody, MAPK 9 antibody, Mapk9 antibody, Mitogen activated protein kinase 9 antibody, Mitogen-activated protein kinase 9 antibody, MK09_HUMAN antibody, P54a antibody, p54aSAPK antibody, PRKM9 antibody, Protein kinase, mitogen-activated, 9 antibody, SAPK alpha antibody, SAPK antibody, SAPK1a antibody, Stress activated protein kinase 1a antibody, Stress-activated protein kinase JNK2 antibody

UniProt: P45984

Pathways: MAPK Signalweg, WNT Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteine