MOBKL1A Antikörper (AA 2-216)

Produktnummer ABIN7160120

Produktdetails anti-MOBKL1A Antikörper

Target: MOBKL1A (MOB1B) (MOB Kinase Activator 1B (MOB1B))

Bindungsspezifität: AA 2-216

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MOBKL1A Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human MOB kinase activator 1B protein (2-216AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:500-1:2000, IF:1:200-1:500, IP:1:200-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MOBKL1A

Target: MOBKL1A (MOB1B) (MOB Kinase Activator 1B (MOB1B))

Andere Bezeichnung: MOB1B (MOB1B Produkte)

Hintergrund:

Background: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Aliases: MATS 2 antibody, MATS2 antibody, MGC33910 antibody, Mob 1A antibody, Mob 1B antibody, MOB 4A antibody, MOB kinase activator 1B antibody, Mob1 homolog 1A antibody, MOB1 Mps One Binder homolog B antibody, MOB1 Mps one binder kinase activator like 1A antibody, Mob1A antibody, Mob1B antibody, MOBKL 1A antibody, MOBKL1A antibody, MOL1A_HUMAN antibody, Mps one binder kinase activator like 1A antibody, Mps one binder kinase activator-like 1A antibody, Protein Mob4A antibody

UniProt: Q7L9L4