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NLRP1 Antikörper (AA 1-146) (FITC)

NLRP1 Reaktivität: Human Wirt: Kaninchen Polyclonal FITC
Produktnummer ABIN7160819
  • Target Alle NLRP1 Antikörper anzeigen
    NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))
    Bindungsspezifität
    • 15
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-146
    Reaktivität
    • 43
    • 19
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 41
    • 2
    • 1
    Kaninchen
    Klonalität
    • 44
    Polyklonal
    Konjugat
    • 18
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NLRP1 Antikörper ist konjugiert mit FITC
    Applikation
    Bitte anfragen
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human NACHT, LRR and PYD domains-containing protein 1 protein (1-146AA)
    Isotyp
    IgG
    Top Product
    Discover our top product NLRP1 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))
    Andere Bezeichnung
    NLRP1 (NLRP1 Produkte)
    Synonyme
    CARD7 antikoerper, CIDED antikoerper, CLR17.1 antikoerper, DEFCAP antikoerper, DEFCAP-L/S antikoerper, NAC antikoerper, NALP1 antikoerper, PP1044 antikoerper, SLEV1 antikoerper, VAMAS1 antikoerper, NLR family pyrin domain containing 1 antikoerper, NLRP1 antikoerper, Nlrp1 antikoerper
    Hintergrund

    Background: As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitement of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762).

    Aliases: CARD 7 antibody, CARD7 antibody, Caspase recruitment domain protein 7 antibody, Caspase recruitment domain-containing protein 7 antibody, CLR17.1 antibody, Death effector filament forming Ced 4 like apoptosis protein antibody, Death effector filament-forming ced-4-like apoptosis protein antibody, DEFCAP antibody, DEFCAP L/S antibody, DKFZp586O1822 antibody, KIAA0926 antibody, LRR and PYD domains-containing protein 1 antibody, NAC alpha/beta/gamma/delta antibody, NAC antibody, NACHT antibody, NACHT leucine rich repeat and PYD containing 1 antibody, NACHT leucine rich repeat and PYD pyrin domain containing 1 antibody, NACHT leucine rich repeat and pyrin domain containing 1 antibody, NACHT LRR and PYD containing protein 1 antibody, NALP 1 antibody, NALP1 antibody, NALP1_HUMAN antibody, NLR family pyrin domain containing 1 antibody, NLRP 1 antibody, NLRP1 antibody, NLRP1 protein antibody, Nucleotide binding domain and caspase recruitment domain antibody, Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 1 antibody, Nucleotide-binding domain and caspase recruitment domain antibody, PP 1044 antibody, PP1044 antibody

    UniProt
    Q9C000
    Pathways
    Positive Regulation of Endopeptidase Activity, Inflammasome
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