NLRP2 Antikörper (AA 1-220)

Produktnummer ABIN7160825

Produktdetails anti-NLRP2 Antikörper

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Bindungsspezifität: AA 1-220

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human NACHT, LRR and PYD domains-containing protein 2 protein (1-220AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NLRP2

Target: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Andere Bezeichnung: NLRP2 (NLRP2 Produkte)

Hintergrund:

Background: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.

Aliases: CLR19.9 antibody, FLJ20510 antibody, Leucine rich repeat and PYD containing protein 2 antibody, LRR and PYD domains-containing protein 2 antibody, NACHT antibody, NACHT domain antibody, NACHT leucine rich repeat and PYD containing 2 antibody, NACHT LRR and PYD domains containing protein 2 antibody, NALP2 antibody, NALP2_HUMAN antibody, NBS1 antibody, NLR family pyrin domain containing 2 antibody, NLRP2 antibody, Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2 antibody, Nucleotide-binding site protein 1 antibody, PAN1 antibody, PYPAF2 antibody, PYRIN containing APAF1 like protein2 antibody, PYRIN domain and NACHT domain-containing protein 1 antibody, PYRIN-containing APAF1-like protein 2 antibody

UniProt: Q9NX02

Pathways: Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome