NLRP6 Antikörper (AA 154-306)

Produktnummer ABIN7160831

Produktdetails anti-NLRP6 Antikörper

Target: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Bindungsspezifität: AA 154-306

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP6 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human NACHT, LRR and PYD domains-containing protein 6 protein (154-306AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NLRP6

Target: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Andere Bezeichnung: NLRP6 (NLRP6 Produkte)

Synonyme: NLRP6 antikoerper, NALP6 antikoerper, AVR antikoerper, CLR11.4 antikoerper, NAVR antikoerper, NAVR/AVR antikoerper, PAN3 antikoerper, PYPAF5 antikoerper, AI504961 antikoerper, Avr antikoerper, Nalp6 antikoerper, Navr antikoerper, Navr/Avr antikoerper, Pypaf5 antikoerper, NLR family pyrin domain containing 6 antikoerper, NLR family, pyrin domain containing 6 antikoerper, NLRP6 antikoerper, Nlrp6 antikoerper

Hintergrund:

Background: As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity) (PubMed:12387869). Essential for gut mucosal self-renewal and proliferation. Maintains intestinal homeostasis and a healthy intestinal microbiota. This function is, at least partially, mediated by IL18, and not IL1B, produced by nonhematopoietic cells. Influences intestinal barrier function and microbial homeostasis through the regulation of goblet cell mucus secretion. Acts by promoting autophagy in goblet cells, an essential step for mucus granule exocytosis. Its role in goblet cell physiology is inflammasome-dependent, but IL1B- and IL18-independent. During systemic bacterial infections, may negatively regulate inflammatory signaling and inhibit the influx of monocytes and neutrophils to the circulation and to the peritoneum. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity).

Aliases: Angiotensin II/vasopressin receptor antibody, AVR antibody, CLR11.4 antibody, NACHT, leucine rich repeat and PYD containing 6 antibody, NACHT, LRR and PYD containing protein 6 antibody, NACHT, LRR and PYD domains-containing protein 6 antibody, NAVR antibody, NAVR/AVR antibody, NLR family, pyrin domain containing 6 antibody, Nlrp6 antibody, NLRP6_HUMAN antibody, Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 6 antibody, PAN3 antibody, PYPAF5 antibody, PYRIN containing APAF1 like protein 5 antibody, PYRIN-containing APAF1-like protein 5 antibody

UniProt: P59044

Pathways: Inflammasome