NPHP4 Antikörper (AA 397-543) (Biotin)

Produktnummer ABIN7161159

Produktdetails anti-NPHP4 Antikörper (Biotin)

Target: NPHP4 (Nephronophthisis 4 (NPHP4))

Bindungsspezifität: AA 397-543

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPHP4 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Nephrocystin-4 protein (397-543AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NPHP4

Target: NPHP4 (Nephronophthisis 4 (NPHP4))

Andere Bezeichnung: NPHP4 (NPHP4 Produkte)

Synonyme: NPHP4 antikoerper, POC10 antikoerper, SLSN4 antikoerper, 4930564O18Rik antikoerper, nmf192 antikoerper, nephrocystin 4 antikoerper, nephrocystin-4 antikoerper, nephronophthisis 4 (juvenile) homolog (human) antikoerper, NPHP4 antikoerper, LOC100184720 antikoerper, Nphp4 antikoerper

Hintergrund:

Background: Involved in the organization of apical junctions, the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462).

Aliases: KIAA0673 antibody, Nephrocystin-4 antibody, nephronophthisis 4 antibody, Nephroretinin antibody, NPHP4 antibody, NPHP4_HUMAN antibody, POC10 antibody, POC10 centriolar protein homolog antibody, SLSN4 antibody

UniProt: O75161