NPHP4 Antikörper (AA 397-543) (FITC)
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- Target Alle NPHP4 Antikörper anzeigen
- NPHP4 (Nephronophthisis 4 (NPHP4))
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Bindungsspezifität
- AA 397-543
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NPHP4 Antikörper ist konjugiert mit FITC
- Applikation
- Bitte anfragen
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human Nephrocystin-4 protein (397-543AA)
- Isotyp
- IgG
- Top Product
- Discover our top product NPHP4 Primärantikörper
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- NPHP4 (Nephronophthisis 4 (NPHP4))
- Andere Bezeichnung
- NPHP4 (NPHP4 Produkte)
- Synonyme
- NPHP4 antikoerper, POC10 antikoerper, SLSN4 antikoerper, 4930564O18Rik antikoerper, nmf192 antikoerper, nephrocystin 4 antikoerper, nephrocystin-4 antikoerper, nephronophthisis 4 (juvenile) homolog (human) antikoerper, NPHP4 antikoerper, LOC100184720 antikoerper, Nphp4 antikoerper
- Hintergrund
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Background: Involved in the organization of apical junctions, the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462).
Aliases: KIAA0673 antibody, Nephrocystin-4 antibody, nephronophthisis 4 antibody, Nephroretinin antibody, NPHP4 antibody, NPHP4_HUMAN antibody, POC10 antibody, POC10 centriolar protein homolog antibody, SLSN4 antibody
- UniProt
- O75161
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