Norrie Disease (Pseudoglioma) Antikörper (AA 25-133)
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- Target Alle Norrie Disease (Pseudoglioma) (NDP) Antikörper anzeigen
- Norrie Disease (Pseudoglioma) (NDP)
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Bindungsspezifität
- AA 25-133
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Norrie Disease (Pseudoglioma) Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (IHC)
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human Norrin protein (25-133AA)
- Isotyp
- IgG
- Top Product
- Discover our top product NDP Primärantikörper
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- Applikationshinweise
- Recommended dilution: IHC:1:20-1:200,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- Norrie Disease (Pseudoglioma) (NDP)
- Andere Bezeichnung
- NDP (NDP Produkte)
- Synonyme
- EVR2 antikoerper, FEVR antikoerper, ND antikoerper, evr2 antikoerper, fevr antikoerper, xnorrin antikoerper, Ndph antikoerper, RGD1563968 antikoerper, NDP, norrin cystine knot growth factor antikoerper, Norrie disease (pseudoglioma) L homeolog antikoerper, Norrie disease (pseudoglioma) (human) antikoerper, NDP antikoerper, ndp.L antikoerper, Ndp antikoerper
- Hintergrund
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Background: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Aliases: EVR2 antibody, Exudative vitreoretinopathy 2 (X linked) antibody, FEVR antibody, ND antibody, NDP antibody, NDP_HUMAN antibody, Norrie disease (pseudoglioma) antibody, Norrie disease protein antibody, Norrin antibody, Norrin precursor antibody, X linked exudative vitreoretinopathy 2 protein antibody, X-linked exudative vitreoretinopathy 2 protein antibody
- UniProt
- Q00604
- Pathways
- Sensory Perception of Sound
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