RORB Antikörper (AA 1-269) (Biotin)

Produktnummer ABIN7161878

Produktdetails anti-RORB Antikörper (Biotin)

Target: RORB (RAR-Related Orphan Receptor B (RORB))

Bindungsspezifität: AA 1-269

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RORB Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Nuclear receptor ROR-beta protein (1-269AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RORB

Target: RORB (RAR-Related Orphan Receptor B (RORB))

Andere Bezeichnung: RORB (RORB Produkte)

Synonyme: RORB antikoerper, Nr1f2 antikoerper, LOC100226267 antikoerper, NR1F2 antikoerper, ROR-BETA antikoerper, RZR-BETA antikoerper, RZRB antikoerper, bA133M9.1 antikoerper, nr1f2 antikoerper, rzrb antikoerper, sb:eu943 antikoerper, RZR-beta antikoerper, Rorbeta antikoerper, RAR related orphan receptor B antikoerper, RAR-related orphan receptor B antikoerper, RAR-related orphan receptor beta antikoerper, RORB antikoerper, Rorb antikoerper, rorb antikoerper

Hintergrund:

Background: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5\'-AGGTCA-3\' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).

Aliases: bA133M9.1 antibody, NR1F2 antibody, Nuclear receptor ROR-beta antibody, Nuclear receptor RZR beta antibody, Nuclear receptor RZR-beta antibody, Nuclear receptor subfamily 1 group F member 2 antibody, OTTHUMP00000021486 antibody, RAR related orphan receptor B antibody, RAR related orphan receptor beta antibody, Retinoic acid binding receptor beta antibody, Retinoid-related orphan receptor-beta antibody, ROR BETA antibody, Rorb antibody, RORB_HUMAN antibody, RZR BETA antibody, RZRB antibody

UniProt: Q92753

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway