OTUD7B Antikörper (AA 235-347)

Produktnummer ABIN7162338

Produktdetails anti-OTUD7B Antikörper

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Bindungsspezifität: AA 235-347

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OTUD7B Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human OTU domain-containing protein 7B protein (235-347AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu OTUD7B

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Andere Bezeichnung: OTUD7B (OTUD7B Produkte)

Synonyme: OTUD7B antikoerper, ZA20D1 antikoerper, za20d1 antikoerper, zgc:152772 antikoerper, cezanne antikoerper, CEZANNE antikoerper, 2900060B22Rik antikoerper, 4930463P07Rik antikoerper, AI462125 antikoerper, Trabid2 antikoerper, Za20d1 antikoerper, RGD1308111 antikoerper, OTU deubiquitinase 7B antikoerper, OTU domain containing 7B antikoerper, OTUD7B antikoerper, otud7b antikoerper, Otud7b antikoerper

Hintergrund:

Background: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates \\\'Lys-48\\\'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward \\\'Lys-11\\\', \\\'Lys-48\\\' and \\\'Lys-63\\\'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with \\\'Lys-11\\\'-linked polyubiquitin chains (in vitro), however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.

Aliases: Cellular zinc finger anti NF kappa B protein antibody, Cellular zinc finger anti-NF-kappa-B protein antibody, CEZANNE antibody, HGNC:16683 antibody, OTU domain containing protein 7B antibody, OTU domain-containing protein 7B antibody, OTU7B_HUMAN antibody, OTUD7B antibody, ZA20D1 antibody, Zinc finger A20 domain containing protein 1 antibody, Zinc finger A20 domain-containing protein 1 antibody, Zinc finger protein Cezanne antibody

UniProt: Q6GQQ9