OTUD7B Antikörper (AA 235-347) (Biotin)

Produktnummer ABIN7162339

Produktdetails anti-OTUD7B Antikörper (Biotin)

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Bindungsspezifität: AA 235-347

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OTUD7B Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human OTU domain-containing protein 7B protein (235-347AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu OTUD7B

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Andere Bezeichnung: OTUD7B (OTUD7B Produkte)

Hintergrund:

Background: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates \'Lys-48\'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward \'Lys-11\', \'Lys-48\' and \'Lys-63\'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with \'Lys-11\'-linked polyubiquitin chains (in vitro), however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.

Aliases: Cellular zinc finger anti NF kappa B protein antibody, Cellular zinc finger anti-NF-kappa-B protein antibody, CEZANNE antibody, HGNC:16683 antibody, OTU domain containing protein 7B antibody, OTU domain-containing protein 7B antibody, OTU7B_HUMAN antibody, OTUD7B antibody, ZA20D1 antibody, Zinc finger A20 domain containing protein 1 antibody, Zinc finger A20 domain-containing protein 1 antibody, Zinc finger protein Cezanne antibody

UniProt: Q6GQQ9