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PER3 Antikörper (AA 1-131) (Biotin)

PER3 Reaktivität: Human ELISA Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN7162912
  • Target Alle PER3 Antikörper anzeigen
    PER3 (Period Homolog 3 (PER3))
    Bindungsspezifität
    • 15
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-131
    Reaktivität
    • 49
    • 29
    • 14
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 44
    • 6
    Kaninchen
    Klonalität
    • 45
    • 5
    Polyklonal
    Konjugat
    • 26
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PER3 Antikörper ist konjugiert mit Biotin
    Applikation
    • 37
    • 20
    • 13
    • 13
    • 10
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    ELISA
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Period circadian protein homolog 3 protein (1-131AA)
    Isotyp
    IgG
    Top Product
    Discover our top product PER3 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    PER3 (Period Homolog 3 (PER3))
    Andere Bezeichnung
    PER3 (PER3 Produkte)
    Synonyme
    period3 antikoerper, rper3 antikoerper, GIG13 antikoerper, 2810049O06Rik antikoerper, mPer3 antikoerper, period circadian clock 3 antikoerper, period circadian regulator 3 antikoerper, Per3 antikoerper, PER3 antikoerper
    Hintergrund

    Background: Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots \'circa\' (about) and \'diem\' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for \'timegivers\'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5\'-CACGTG-3\') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme.

    Aliases: 2810049O06Rik antibody, Cell growth inhibiting gene 13 protein antibody, Cell growth-inhibiting gene 13 protein antibody, Circadian clock protein PERIOD 3 antibody, GIG13 antibody, gPER3 antibody, Growth inhibiting protein 13 antibody, HGNC:8847 antibody, hPER3 antibody, mPer3 antibody, Per3 antibody, PER3_HUMAN antibody, Period 3 antibody, Period circadian clock 3 antibody, Period circadian protein 3 antibody, Period circadian protein homolog 3 antibody, Period homolog 3 (Drosophila) antibody, Period homolog 3 antibody, Period homolog 3, Drosophila antibody, Period3 antibody

    UniProt
    P56645
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