ETHE1 Antikörper (AA 8-254)

Produktnummer ABIN7163017

Produktdetails anti-ETHE1 Antikörper

Target: ETHE1 (Ethylmalonic Encephalopathy 1 (ETHE1))

Bindungsspezifität: AA 8-254

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ETHE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Persulfide dioxygenase ETHE1, mitochondrial protein (8-254AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ETHE1

Target: ETHE1 (Ethylmalonic Encephalopathy 1 (ETHE1))

Andere Bezeichnung: ETHE1 (ETHE1 Produkte)

Synonyme: zgc:85680 antikoerper, HSCO antikoerper, YF13H12 antikoerper, 0610025L15Rik antikoerper, Hsco antikoerper, ETHE1, persulfide dioxygenase antikoerper, ethylmalonic encephalopathy 1 antikoerper, Ethe1 antikoerper, ethe1 antikoerper, ETHE1 antikoerper

Hintergrund:

Background: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897).

Aliases: Ethe1 antibody, ETHE1 protein, mitochondrial precursor antibody, ETHE1_HUMAN antibody, ethylmalonic encephalopathy 1 antibody, Ethylmalonic encephalopathy protein 1 antibody, hepatoma subtracted clone one antibody, Hepatoma subtracted clone one protein antibody, HSCO antibody, mitochondrial antibody, Protein ETHE1 antibody, Protein ETHE1 mitochondrial antibody, YF13H12 antibody

UniProt: O95571