NOXA Antikörper (AA 1-136)

Produktnummer ABIN7163088

Produktdetails anti-NOXA Antikörper

Target: NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))

Bindungsspezifität: AA 1-136

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOXA Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Phorbol-12-myristate-13-acetate-induced protein 1 protein (1-136AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NOXA

Target: NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))

Andere Bezeichnung: PMAIP1 (PMAIP1 Produkte)

Synonyme: TN3 antikoerper, PMAIP1 antikoerper, zgc:162379 antikoerper, APR antikoerper, NOXA antikoerper, Noxa antikoerper, phorbol-12-myristate-13-acetate-induced protein 1 antikoerper, PMAIP1 antikoerper, pmaip1 antikoerper, Pmaip1 antikoerper

Hintergrund:

Background: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

Aliases: Adult T cell leukemia derived PMA responsive antibody, APR antibody, APR_HUMAN antibody, ATL-derived antibody, Immediate early response protein APR antibody, Immediate-early-response protein APR antibody, NOXA antibody, Phorbol 12 myristate 13 acetate induced protein 1 antibody, Phorbol-12-myristate-13-acetate-induced protein 1 antibody, PMA induced protein 1 antibody, PMA-induced protein 1 antibody, PMA-responsive gene antibody, Pmaip1 antibody, Protein Noxa antibody

UniProt: Q13794

Pathways: p53 Signalweg, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus