Pleiotrophin Antikörper (AA 33-168)

Produktnummer ABIN7163691

Produktdetails anti-Pleiotrophin Antikörper

Target: Pleiotrophin (PTN)

Bindungsspezifität: AA 33-168

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Pleiotrophin Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Pleiotrophin protein (33-168AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Pleiotrophin

Target: Pleiotrophin (PTN)

Andere Bezeichnung: PTN (PTN Produkte)

Synonyme: zHBNF antikoerper, zgc:111787 antikoerper, harp antikoerper, hbnf antikoerper, X-PTF antikoerper, hbgf8 antikoerper, negf1 antikoerper, ptn antikoerper, PTN antikoerper, HARP antikoerper, HBGF8 antikoerper, HBNF antikoerper, NEGF1 antikoerper, PTN-A antikoerper, HB-GAM antikoerper, HBBM antikoerper, HBGF-8 antikoerper, OSF-1 antikoerper, HBBN antikoerper, OSF antikoerper, Osf-1 antikoerper, Osf1 antikoerper, Hbnf antikoerper, pleiotrophin antikoerper, pleiotrophin L homeolog antikoerper, ptn antikoerper, PTN antikoerper, ptn.L antikoerper, Ptn antikoerper

Hintergrund:

Background: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).

Aliases: HARP antibody, HB-GAM antibody, HBBM antibody, HBGAM antibody, HBGF-8 antibody, HBGF8 antibody, HBNF antibody, HBNF-1 antibody, HBNF1 antibody, heparin affin regulatory protein antibody, Heparin binding growth associated molecule antibody, Heparin binding growth factor 8 antibody, Heparin binding neurite outgrowth promoting factor 1 antibody, Heparin-binding brain mitogen antibody, Heparin-binding growth factor 8 antibody, Heparin-binding growth-associated molecule antibody, heparin-binding neurite outgrowth promoting factor antibody, Heparin-binding neurite outgrowth-promoting factor 1 antibody, NEGF1 antibody, Neurite growth promoting factor 1 antibody, Neurite outgrowth-promoting factor, heparin-binding antibody, OSF-1 antibody, OSF1 antibody, Osteoblast-specific factor 1 antibody, pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) antibody, Pleiotrophin antibody, PTN antibody, PTN_HUMAN antibody

UniProt: P21246

Pathways: RTK Signalweg