PCGF1 Antikörper (AA 113-187)

Produktnummer ABIN7163794

Produktdetails anti-PCGF1 Antikörper

Target: PCGF1 (Polycomb Group Ring Finger 1 (PCGF1))

Bindungsspezifität: AA 113-187

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCGF1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Polycomb group RING finger protein 1 protein (113-187AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PCGF1

Target: PCGF1 (Polycomb Group Ring Finger 1 (PCGF1))

Andere Bezeichnung: PCGF1 (PCGF1 Produkte)

Synonyme: PCGF1 antikoerper, 2010002K04Rik antikoerper, NSPC1 antikoerper, RNF3A-2 antikoerper, RNF68 antikoerper, AU024121 antikoerper, Nspc1 antikoerper, nspc1 antikoerper, si:zc207o21.2 antikoerper, polycomb group ring finger 1 antikoerper, polycomb group ring finger 1 L homeolog antikoerper, PCGF1 antikoerper, pcgf1 antikoerper, Pcgf1 antikoerper, pcgf1.L antikoerper

Hintergrund:

Background: Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6, this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A \\\'Lys-119\\\', rendering chromatin heritably changed in its expressibility. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479).

Aliases: PCGF1 antibody, NSPC1 antibody, RNF68 antibody, Polycomb group RING finger protein 1 antibody, Nervous system Polycomb-1 antibody, NSPc1 antibody, RING finger protein 68 antibody

UniProt: Q9BSM1