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PD-L1 Antikörper (AA 19-238)

Name: PD-L1 Antikörper (AA 19-238)
Brand: antibodies-online
SKU: ABIN7164674
Price: 385 EUR
Availability: InStock

PD-L1 Reaktivität: Human WB, FACS, IHC, ELISA, IF Wirt: Maus Monoclonal 9B5F4 unconjugated

Western Blot Positive WB detected in: A549 whole cell lysate, PC-3 whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, Hela whole cell lysate All lanes: PD-L1 antibody at 1:2500 Secondary Goat polyclonal to Mouse IgG at 1/10000 dilution Predicted band size: 33 kDa Observed band size: 55 kDa (PD-L1 Antikörper (AA 19-238))

Overlay histogram showing A549 cells stained with ABIN7164674 (red line) at 1:150. (PD-L1 Antikörper (AA 19-238))

FACS

Western Blot Positive WB detected in: Hela whole cell lysate All lanes: PD-L1 antibody at 1:1000, 1:2000, 1:4000 Secondary Goat polyclonal to Mouse IgG at 1/10000 dilution Predicted band size: 33 kDa Observed band size: 55 kDa (PD-L1 Antikörper (AA 19-238))

IHC image of ABIN7164674 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. (PD-L1 Antikörper (AA 19-238))

IHC

IHC image of ABIN7164674 diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. (PD-L1 Antikörper (AA 19-238))

IHC

Immunofluorescence staining of 293 cells with ABIN7164674 at 1:100, counter-stained with DAPI. (PD-L1 Antikörper (AA 19-238))

Immunofluorescence staining of A549 cells with ABIN7164674 at 1:100, counter-stained with DAPI. (PD-L1 Antikörper (AA 19-238))

Immunofluorescence staining of Hela cells with ABIN7164674 at 1:100, counter-stained with DAPI. (PD-L1 Antikörper (AA 19-238))

Overlay histogram showing 293 cells stained with ABIN7164674 (red line) at 1:150. (PD-L1 Antikörper (AA 19-238))

FACS

9 Abbildungen

Produktnummer ABIN7164674

Datenblatt (PDF)

Target Alle PD-L1 Antikörper anzeigen

PD-L1 (CD274 (PD-L1))
Bindungsspezifität
29

16

15

13

11

9

7

7

5

5

4

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 19-238
Reaktivität
168

116

62

6

5

5

5

1

1
Human
Wirt
131

56

21

4

2

1
Maus
Passende Sekundärantikörper
Klonalität
113

100

2
Monoklonal
Konjugat
92

17

14

11

9

5

4

4

4

4

4

4

4

4

4

4

4

4

3

2

2

2

2

2

2

2

1

1
Dieser PD-L1 Antikörper ist unkonjugiert
Applikation
133

104

55

40

36

28

18

16

13

12

10

7

6

5

3

3

2

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität

Human

Aufreinigung

Protein G purified

Immunogen

Recombinant Human Programmed cell death 1 ligand 1 protein (19-238AA)

Klon

9B5F4

Isotyp

IgG2b

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PD-L1 Reaktivität: Human FACS, ELISA Wirt: Maus Monoclonal 7D2A10 unconjugated

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KO Validated PD-L1 Reaktivität: Human WB, FACS, ICC, IF, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-CD274 (PD-L1) (AA 19-238) antibody
PD-L1 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-CD274 (PD-L1) (AA 201-290) antibody
PD-L1 Reaktivität: Maus, Ratte WB, ELISA, IF (cc), IHC (p), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

Recommended dilution: WB:1:1000-1:5000, IHC:1:50-1:200, IF:1:50-1:200, FC:1:100-1:300,

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel

ProClin

Vorsichtsmaßnahmen

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C,-80 °C

Informationen zur Lagerung

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target

PD-L1 (CD274 (PD-L1))

Andere Bezeichnung

PD-L1 (PD-L1 Produkte)

Synonyme

B7-H antikoerper, B7H1 antikoerper, PD-L1 antikoerper, PDCD1L1 antikoerper, PDCD1LG1 antikoerper, PDL1 antikoerper, A530045L16Rik antikoerper, B7h1 antikoerper, Pdcd1l1 antikoerper, Pdcd1lg1 antikoerper, Pdl1 antikoerper, RGD1566211 antikoerper, CD274 molecule antikoerper, CD274 antigen antikoerper, programmed cell death 1 ligand 2 antikoerper, CD274 antikoerper, Cd274 antikoerper, PDCD1LG2 antikoerper

Hintergrund

Background: Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077)
Aliases: Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (B7 homolog 1) (B7-H1) (CD antigen CD274), CD274, B7H1 PDCD1L1 PDCD1LG1 PDL1

UniProt

Q9NZQ7

Pathways

Cancer Immune Checkpoints