PSME3 Antikörper (AA 2-252)

Produktnummer ABIN7164919

Produktdetails anti-PSME3 Antikörper

Target: PSME3

Bindungsspezifität: AA 2-252

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSME3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Proteasome activator complex subunit 3 protein (2-252AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PSME3

Target: PSME3

Andere Bezeichnung: PSME3 (PSME3 Produkte)

Synonyme: AA410043 antikoerper, AU020960 antikoerper, Ki antikoerper, PA28gamma antikoerper, REGgamma antikoerper, pa28g antikoerper, Ab2-371 antikoerper, PA28-gamma antikoerper, PA28G antikoerper, REG-GAMMA antikoerper, psme3b antikoerper, proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) antikoerper, proteasome activator subunit 3 antikoerper, proteasome activator subunit 3 S homeolog antikoerper, Psme3 antikoerper, PSME3 antikoerper, psme3.S antikoerper

Hintergrund:

Background: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.

Aliases: 11S regulator complex gamma subunit antibody, 11S regulator complex subunit gamma antibody, Activator of multicatalytic protease subunit 3 antibody, Ki antibody, Ki antigen antibody, Ki nuclear autoantigen antibody, Ki, PA28 gamma antibody, PA28 gamma antibody, PA28g antibody, PA28gamma antibody, Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) antibody, Proteasome (prosome, macropain) activator subunit 3 antibody, Proteasome activator 28 gamma antibody, Proteasome activator 28 subunit gamma antibody, Proteasome activator complex subunit 3 antibody, Proteasome activator subunit 3 antibody, PSME3 antibody, PSME3_HUMAN antibody, REG GAMMA antibody, REG-gamma antibody

UniProt: P61289

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA