PRMT1 Antikörper (AA 1-248)

Produktnummer ABIN7165056

Produktdetails anti-PRMT1 Antikörper

Target: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Bindungsspezifität: AA 1-248

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRMT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Protein arginine N-methyltransferase 1 protein (1-248AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PRMT1

Target: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Andere Bezeichnung: PRMT1 (PRMT1 Produkte)

Synonyme: ANM1 antikoerper, HCP1 antikoerper, HRMT1L2 antikoerper, IR1B4 antikoerper, 6720434D09Rik antikoerper, AW214366 antikoerper, Hrmt1l2 antikoerper, Mrmt1 antikoerper, 3E10 antikoerper, anm1 antikoerper, hcp1 antikoerper, hrmt1l2 antikoerper, ir1b4 antikoerper, prmt1 antikoerper, prmt1b antikoerper, xPRMT1b antikoerper, xprmt1 antikoerper, xPRMT1 antikoerper, ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 1A antikoerper, ATPRMT1A antikoerper, F6F22.30 antikoerper, F6F22_30 antikoerper, protein arginine methyltransferase 1A antikoerper, DDBDRAFT_0183976 antikoerper, DDBDRAFT_0235399 antikoerper, DDB_0183976 antikoerper, DDB_0235399 antikoerper, PRMT1 antikoerper, DKFZp459J1326 antikoerper, fb39h07 antikoerper, wu:fb39h07 antikoerper, zf1 antikoerper, zgc:66201 antikoerper, protein arginine methyltransferase 1 antikoerper, protein arginine N-methyltransferase 1 antikoerper, protein arginine methyltransferase 1 L homeolog antikoerper, protein arginine methyltransferase 1 S homeolog antikoerper, protein arginine methyltransferase 1A antikoerper, protein arginine N-methyltransferase-1 antikoerper, protein arginine N-methyltransferase antikoerper, protein arginine methyltransferase antikoerper, PRMT1 antikoerper, Prmt1 antikoerper, prmt1.L antikoerper, prmt1.S antikoerper, PRMT1A antikoerper, prm-1 antikoerper, EDI_007800 antikoerper, Smp_029240.3 antikoerper, prmt1 antikoerper

Hintergrund:

Background: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 \\\'Arg-4\\\' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).

Aliases: ANM 1 antibody, ANM1 antibody, ANM1_HUMAN antibody, HCP 1 antibody, HCP1 antibody, Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2 antibody, Heterogeneous nuclear ribonucleoproteins methyltransferase like 2 antibody, Heterogeneous nuclear ribonucleoproteins methyltransferase like2 antibody, Histone-arginine N-methyltransferase PRMT1 antibody, HMT 2 antibody, HMT1 (hnRNP methyltransferase S. cerevisiae) like 2 antibody, HMT1 hnRNP methyltransferase antibody, HMT1 hnRNP methyltransferase like 2 (S. cerevisiae) antibody, HMT1 hnRNP methyltransferase like 2 antibody, HMT2 antibody, HRMT1 L2 antibody, HRMT1L 2 antibody, HRMT1L2 antibody, Human mRNA for suppressor for yeast mutant antibody, Human mRNA for suppressor for yeast mutant complete cds antibody, Interferon receptor 1 bound protein 4 antibody, Interferon receptor 1 bound protein4 antibody, Interferon receptor 1-bound protein 4 antibody, Interferon receptor 1bound protein 4 antibody, IR1 B4 antibody, IR1B 4 antibody, IR1B4 antibody, Mrmt 1 antibody, Mrmt1 antibody, PRMT 1 antibody, PRMT1 antibody, Protein arginine methyltransferase 1 antibody, Protein arginine N methyltransferase 1 antibody, Protein arginine N methyltransferase1 antibody, Protein arginine N-methyltransferase 1 antibody, R1B4 antibody, S. cerevisiae like 2 antibody

UniProt: Q99873