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ECT2 Antikörper (AA 283-453) (HRP)

ECT2 Reaktivität: Human ELISA Wirt: Kaninchen Polyclonal HRP
Produktnummer ABIN7165316
  • Target Alle ECT2 Antikörper anzeigen
    ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))
    Bindungsspezifität
    • 15
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 283-453
    Reaktivität
    • 61
    • 12
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 56
    • 4
    • 1
    Kaninchen
    Klonalität
    • 57
    • 4
    Polyklonal
    Konjugat
    • 23
    • 8
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ECT2 Antikörper ist konjugiert mit HRP
    Applikation
    • 47
    • 23
    • 19
    • 14
    • 14
    • 8
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human Protein ECT2 protein (283-453AA)
    Isotyp
    IgG
    Top Product
    Discover our top product ECT2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))
    Andere Bezeichnung
    ECT2 (ECT2 Produkte)
    Synonyme
    ECT2 antikoerper, arhgef31 antikoerper, xect2 antikoerper, AI528536 antikoerper, mKIAA4037 antikoerper, ARHGEF31 antikoerper, ect2 antikoerper, epithelial cell transforming 2 antikoerper, ect2 oncogene antikoerper, epithelial cell transforming 2 S homeolog antikoerper, ECT2 antikoerper, ect2 antikoerper, Ect2 antikoerper, ect2.S antikoerper
    Hintergrund

    Background: Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly, regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity, participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

    Aliases: ECT2Protein ECT2 antibody, Epithelial cell-transforming sequence 2 oncogene antibody

    UniProt
    Q9H8V3
    Pathways
    Neurotrophin Signalübertragung, Cell-Cell Junction Organization
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